Our group has been assigned to find the coordination number and geometrical shape of the DMPS. Besides that, we have to find out the systemic name of the DMPS compound and the complex formed when DMPS binds with mercury. Our group consists of ten members and here is the list of the names.
1. Aaron Bong Sing Woei 20575
2. Chong Meng Shin 20804
3. Sabatini Ak Jihob 22218
4. Voon Siaw Hui 22595
5. Lazarus Samuel Anak Ayi 21628
6. Norfatihah Bt. Huzaimah 21778
7. Nurizzati Bt. Razali 21998
8. Hamzah B. Ab Bakar 21021
9. Muhd Zulkhairi B. Junoh 21493
10. Sitti Shaerah Bt. Saripan 22411
Our group has been doing researches on the task given. Belows are the questions and explanations of the answer we have found.
Monday, February 16, 2009
Trigger 1(B)
DMPS
DMPS is registered in Germany with the BGA (their FDA) for the treatment of mercury poisoning but is still an investigational drug in the United States.
DMPS is an acid-molecule with two free sulfhydryl groups that forms complexes with heavy metals such as zinc, copper, arsenic, mercury, cadmium, lead, silver, and tin. DMPS was developed in the 1950s in the former Soviet Union and has been used to effectively treat metal intoxication since the 1960s there. It is a water-soluble complexing agent.
Because it had potential use as antidote for the chemical warfare agent, Lewisite, it was not available outside of the Soviet Union until 1978, at which time Heyl, a small pharmaceutical company in Berlin, Germany started to produce it. It has an abundance of international research data and an excellent safety record in removing mercury from the body and has been used safely in Europe as Dimaval for many years.
Source: http://www.mercola.com/artile/mercury/mercury_elimination.htm
Questions:
3. What is the coordination number of the complex formed when DMPS bond with mercury? Can you predict the complex's geometrical shape?
Refer to the post of Coordination number and Geometrical Shape
4. What is the systemic name of DMPS? Give the systemic name for the complex when DMPS bond with mercury.
Refer to the post of Systemic Name
DMPS
DMPS is registered in Germany with the BGA (their FDA) for the treatment of mercury poisoning but is still an investigational drug in the United States.
DMPS is an acid-molecule with two free sulfhydryl groups that forms complexes with heavy metals such as zinc, copper, arsenic, mercury, cadmium, lead, silver, and tin. DMPS was developed in the 1950s in the former Soviet Union and has been used to effectively treat metal intoxication since the 1960s there. It is a water-soluble complexing agent.
Because it had potential use as antidote for the chemical warfare agent, Lewisite, it was not available outside of the Soviet Union until 1978, at which time Heyl, a small pharmaceutical company in Berlin, Germany started to produce it. It has an abundance of international research data and an excellent safety record in removing mercury from the body and has been used safely in Europe as Dimaval for many years.
Source: http://www.mercola.com/artile/mercury/mercury_elimination.htm
Questions:
3. What is the coordination number of the complex formed when DMPS bond with mercury? Can you predict the complex's geometrical shape?
Refer to the post of Coordination number and Geometrical Shape
4. What is the systemic name of DMPS? Give the systemic name for the complex when DMPS bond with mercury.
Refer to the post of Systemic Name
About DMPS
What is DMPS?
٭ DMPS stands for 2,3- dimercapto-1-propane sulfonic acid.
٭ It has the molecular formula of C3H8O3S3.
٭ DMPS is a chelating agent, which is a substance that binds to heavy metal.
٭ DMPS specifically binds to mercury, lead and arsenic, and forms stable complexes with these
metals, allowing them to be eliminated from the body.
٭ DMPS is water soluble compound, so it can be administered orally.
٭ DMPS stands for 2,3- dimercapto-1-propane sulfonic acid.
٭ It has the molecular formula of C3H8O3S3.
٭ DMPS is a chelating agent, which is a substance that binds to heavy metal.
٭ DMPS specifically binds to mercury, lead and arsenic, and forms stable complexes with these
metals, allowing them to be eliminated from the body.
٭ DMPS is water soluble compound, so it can be administered orally.
Structure of DMPS
How DMPS related to Chelating Therapies...
Chelation Therapies
*DMPS can be used in Chelating Therapy.
*Chelating Therapy is a method of mobilizing and eliminating toxic metals that attach to body tissues.
*Chelation therapy is to determine whether there is an accumulation of toxic metals in body tissues.
*Heavy metal like mercury can be removed from the body tissues by binding of DMPS with the heavy metal and form complexes which will be excreted out from our body.
*DMPS can be used in Chelating Therapy.
*Chelating Therapy is a method of mobilizing and eliminating toxic metals that attach to body tissues.
*Chelation therapy is to determine whether there is an accumulation of toxic metals in body tissues.
*Heavy metal like mercury can be removed from the body tissues by binding of DMPS with the heavy metal and form complexes which will be excreted out from our body.
Coordination Number and Geometrical Shape
COORDINATION NUMBER and THE COMPLEX's GEOMETRICAL SHAPE
What is a Coordination Number
٭ The coordination number is the total number of neighbours of a central atom in a molecule or ion (the number of donor atom).
٭ It is defined originally in 1893 by Alfred Werner.
٭ It was determined by simple counting the other atoms to which it is bonded (by either single / multiple bonds).
What is Geometrical Shape?
٭ Geometrical shapes are the shapes resembling or employing the simple rectilinear or arviliner lines/figures used in geometry.
٭ In this case, the complex formed has 4 coordination numbers, in which the possible geometrical shape is tetrahedral or square planar.
٭ The DMPS bind with mercury which is one of transition metal element. So, the geometrical shape is definitely a square planar.
Overall,
When DMPS binds with mercury, it formed complex with 4 coordination numbers and has the geometrical shape of a square planar.
What is a Coordination Number
٭ The coordination number is the total number of neighbours of a central atom in a molecule or ion (the number of donor atom).
٭ It is defined originally in 1893 by Alfred Werner.
٭ It was determined by simple counting the other atoms to which it is bonded (by either single / multiple bonds).
What is Geometrical Shape?
٭ Geometrical shapes are the shapes resembling or employing the simple rectilinear or arviliner lines/figures used in geometry.
٭ In this case, the complex formed has 4 coordination numbers, in which the possible geometrical shape is tetrahedral or square planar.
٭ The DMPS bind with mercury which is one of transition metal element. So, the geometrical shape is definitely a square planar.
Overall,
When DMPS binds with mercury, it formed complex with 4 coordination numbers and has the geometrical shape of a square planar.
Systemic Name
What is systemic name?
The systemic name is a system of naming chemical compound in science of chemistry in general.
The systemic name can be given by using IUPAC nomenclature.
These are the steps in naming DMPS molecule using IUPAC;
1. Identify the parent hydrocarbon chain. (The longest continuous chain of carbon atoms)
2. Identify the functional group and the position of the functional group.
3. Number the carbon atom.
4. There are more than one of the same type of side-chain of mercapto, add the prefix di-.
5. Number is written first before functional group name.
6. This molecule is carboxylic acid because it has SOOOH at the end of the carbon chain. SOOOH is sulfonic acid.
7. So, the systemic name for this compound is 2,3–dimercapto–1–propanesulfonic acid (DMPS).
The systemic name is a system of naming chemical compound in science of chemistry in general.
The systemic name can be given by using IUPAC nomenclature.
These are the steps in naming DMPS molecule using IUPAC;
1. Identify the parent hydrocarbon chain. (The longest continuous chain of carbon atoms)
2. Identify the functional group and the position of the functional group.
3. Number the carbon atom.
4. There are more than one of the same type of side-chain of mercapto, add the prefix di-.
5. Number is written first before functional group name.
6. This molecule is carboxylic acid because it has SOOOH at the end of the carbon chain. SOOOH is sulfonic acid.
7. So, the systemic name for this compound is 2,3–dimercapto–1–propanesulfonic acid (DMPS).
DMPS
What is the complex formed when DMPS binds with Mercury?
The complex compound formed when DMPS binds with mercury is
'bis(2,3-dimercaptopropane-1-sulfonic acid) mercury (IV)'
Structure of bis(2,3-dimercaptopropane-1-sulfonic acid) mercury (IV)
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